It was observed that STAT3 could suppress NK cell-mediated immunosurveillance through downregulating natural killer group 2, member D receptor ligands (NKG2DL) in HT29 colorectal cancer cell line, and STAT3 neutralization activated NK cells via the induction of MHC class I chain-related protein A (MICA), which is the recognition receptor of NK cells (33). Here, MICA is linked to colorectal cancer.