Researchers also constructed EpCAM targeted second-generation CAR and transduced it into NK-92 cells using lentiviral vectors, and they indicated CAR-NK-92 cells can specially kill EpCAM+ colorectal cancer cells and combination with regorafenib can greatly reduce tumor growth in NOD/SCID mice with human colorectal xenograft models (94). The gene discussed is EPCAM; the disease is colorectal cancer.