Although pathogenic variants in NR2F2 are associated with congenital diaphragmatic hernia (CDH),[82] multiple types of congenital heart defects,[83, 84] and with 46,XX sex reversal,[85] duplication of NR2F2 is not known to be associated with a phenotype. This evidence concerns the gene NR2F2 and congenital diaphragmatic hernia.