The SEC63 variant seen in an affected individual (ENST00000369002.4:c.1605dupA, p.Pro536ThrfsTer24) is associated with polycystic liver disease (PCLD).[32] However, renal features are not common in PCLD and any relationship of SEC63 to the IC/BPS phenotype in this individual is unclear.[33] Additional variants in genes with known expression in urogenital tissues and previously reported pathogenic variant interpretations are listed in Table3, with single heterozygous variants in autosomal recessive conditions reported in Table4. Here, SEC63 is linked to Isolated polycystic liver disease.