Darier‐White Disease, an autosomal dominant disease caused by mutations in ATP2A2, is a keratinizing disorder that leads to the formation of small hyperkeratotic papules in seborrheic skin areas but can also affect mucosal membranes, nails, and the genitourinary areas.[35, 36, 37, 38] The histology shows acantholysis, hyperkeratosis, and dyskeratosis (the premature differentiation of keratinocytes).[39, 40] We identified a likely pathogenic variant in ATP2A2 (ENST00000539276.2: c.235G>A, p.Glu79Lys) in two probands (SF355, SF138). The gene discussed is ATP2A2; the disease is Hyperkeratosis.