Most of the proteins acetylated by EP300, such as hypoxia-inducible factor 1α (HIF1α), TP53, STAT3, RELA, MYB, NFKB1, FOXO1, MYOD1, and GATA factors (16), have been demonstrated to play crucial roles in PAH (17), implying EP300 might participate in PAH occurrence. The gene discussed is FOXO1; the disease is pulmonary arterial hypertension.