Since changes in myocardial function and microvascular perfusion in prediabetes and earlyDM have not yet been well studied and whether early intervention with SGLT2 inhibitors can effectively prevent myocardial damage is not clear, in this experimental study, we used conventional ultrasound techniques, 2D-STE and MCE, to evaluate the dynamic evolution of myocardial function and microvascular perfusion and to explore the potential beneficial effect of the SGLT2 inhibitor dapagliflozin (DAPA) in a diabetic rat model. The gene discussed is SLC5A2; the disease is prediabetes syndrome.