Applying a threshold value corresponding to the HV mean value plus 2.5 SD, we revealed that 6% (n = 15) of multiple sclerosis and CIS + patients (HR) and only 0.7% (n = 1) of HV controls exhibited high levels of anti-Kir4.1(e1) IgGs (Fig. 4A). Here, KCNJ10 is linked to in situ carcinoma.