Specifically, a previous study from this cohort found that in cognitively healthy adults (n = 98), less adequate sleep, more sleep problems and greater SOM were associated with higher amyloid burden in the angular gyrus, frontal medial orbital cortex, cingulate gyrus and precuneus when these individual sleep variables were included in separate models that adjusted for age, sex, APOE e4, family history of Alzheimer’s disease and BMI.20 In Aim 3, using the larger sample size now available, none of the individual sleep variables were significantly associated with amyloid burden. The gene discussed is APOE; the disease is Alzheimer disease.