Similar to our current results, a study of 143 community-dwelling participants aged ≥70 years12 found no significant relationship between amyloid-PET burden and nighttime sleep duration, daytime sleep duration, 24-h sleep duration, naps, restless leg syndrome, daytime sleepiness, insomnia symptoms or sleep apnoea risk before and after adjustment for APOE e4 and depressive symptoms using logistic regression models. Here, APOE is linked to restless legs syndrome.