The NDS, volume of cerebral infarction and brain water content were significantly increased in IR group compared with those in Sham group (P<0.05), they were decreased in IL-4 group compared with those in IR group (P<0.05), and they were incrased in 2ME2 group and IL-4+2ME2 group compared with those in IL-4 group (P<0.05) (Figure 1). The gene discussed is IL4; the disease is cerebral infarction.