While, Xu et al. conducted a cohort study on 176 patients with chronic kidney disease and 67 healthy controls and reported increased level of CRP, IL-6 and MDA in addition to decreased levels of SOD and GSHPX (glutathione peroxidase) along with inverse relationship between estimated glomerular filtration rate (eGFR) and MDA associated with positive relationship with SOD and GSH-PX among patients with chronic kidney disease (CKD)72. This evidence concerns the gene SOD1 and chronic kidney disease.