We recommend that iron indices(serum ferritin, serum iron, TIBC and TSAT) with inclusion of C-reactive protein should be incorporated into routine investigations of patients with CKD in order to manage, treat, and monitor absolute and functional iron deficient patients as per KDOQI guidelines.12 Also, patients with poor response to ESA and Iron therapy should be investigated for functional iron deficiency. The gene discussed is CRP; the disease is nutritional disorder.