GPT and cancer: Doxorubicin alters the serum enzymes level (ALT, AST, LDH and CK) and also produces marked morphological changes in cardiac tissue including necrosis, intravascular hemolysis, and congestion of the vessels.33 Likewise, cisplatin is widely used to treat cancer patients and induces neurotoxicity as a side effect.34 Many studies have demonstratedthat cisplatin causes brain damage via several mechanisms, i.e. increase lipid peroxidation, amplify the formation of free radicals and elevate the MDA level.35