LEP and Insulin resistance: Thus, it has been reported that DM and insulin resistance are associated with the overexpression of many cytokines by adipose tissue including tumor necrosis factor-α, interleukin (IL)-1, IL-6, leptin, resistin Monocyte Chemo-attractant (MCP-1), Plasminogen Activator (PAI-1), fibrinogen and angiotensin 27.