We found an association between IL-4R Q576R polymorphism and pediatric asthma risk (GG vs AA: OR = 3.75, 95% CI = 1.89–7.45; AG vs AA: OR = 2.15, 95% CI = 1.36–3.39; the dominant model: OR = 2.25, 95% CI = 1.42–3.57;the recessive model: OR = 3.05, 95% CI = 1.54–6.05). Here, IL4R is linked to asthma.