While IL-4R-deficient mice cannot generate IgE and show defective Th2 responses, implicating that IL-4R plays a critical role in regulating IgE, and Q576R polymorphism could influence signal transduction, thereby elevating asthma risk.28 In addition, the possible effect of Q576R polymorphism could be influenced by gene-gene interaction. Here, IL4R is linked to asthma.