The BRAFV600E mutations that were primarily found in melanomas also occur in brain tumors, which, similar to CD34, mainly affect low-grade glial or glioneuronal tumors, such as GG, DNT, and PA, as well as pediatric PXA and diffuse astrocytoma (Schindler et al., 2011; Drosten and Barbacid, 2020; Xing et al., 2021). Here, CD34 is linked to diffuse astrocytoma.