Although CD34-positive cells have been reported in gliosarcoma and giant cell variant of glioblastoma, or non-neoplastic glioneuronal hamartias or hamartomas, they are particularly represented in low-grade or developmental brain tumors, such as GG, pleomorphic xanthoastrocytoma (PXA), dysembroplastic neuroepithelial tumor (DNT) and pilocytic astrocytoma (PA), all of which are quite associated with chronic epilepsy (Blümcke et al., 1999; Reifenberger et al., 2003; Deb et al., 2006; Giulioni et al., 2019). The gene discussed is CD34; the disease is pleomorphic xanthoastrocytoma.