Inflammatory cytokines, such as CCL5, IL-6, IL-1β, IL-8, TNF-α, INF-γ, and MCP-1, are highly increased in HS patients and animal models, the levels of which correlate with organ failure and a fatal outcome (Lu et al., 2004; Chen et al., 2017). Here, CXCL8 is linked to histiocytic sarcoma.