TPPII is involved in cancer and antigen processing by MHC-I presentation and the presented antigens can be detected by CD8+ T cells, a process that is essential for the detection and destruction of cancer cells or cells infected by viruses (Seifert et al., 2003; Diekmann et al., 2009; Embgenbroich and Burgdorf, 2018). The gene discussed is TPP2; the disease is cancer.