Competing endogenous RNA networks further proved the direct correlations between FN1 and C3, FN1 and pro-fibrotic signaling pathways, including WNT, HIF, PI3K/AKT, MAPK, and TGF-β pathways, in ccRCC (Dong et al., 2021). The gene discussed is FN1; the disease is nonpapillary renal cell carcinoma.