ADAM8 and neoplasm: The five mechanisms involved in the progression of cancer by ADAM8 are (Jin Q. et al., 2020): firstly, the creation of a tumor-friendly microenvironment; secondly, the disassociation of ECM compounds; thirdly, generation of chemical opposition and regulation of extracellular activity of MMPs; fourthly governance of cell motility and adhesion and fifthly, triggering the generation of new blood vessels.