TFEB downregulation and abnormal autophagy have been reported in patients with AD and ALS (Tiribuzi et al., 2014; Wang et al., 2016b), and genetic or pharmacological induction of TFEB attenuates neuronal loss and pathological features in AD and PD mouse models (Wang et al., 2016a; Zhuang et al., 2020). Here, TFEB is linked to Alzheimer disease.