STRA6 is highly expressed in blood-organ barrier structures and organs that require high amounts of retinoid for proper function, such as the retinal pigment epithelium (RPE), reproductive organs, brain, and kidney (Amengual et al., 2014; Kelly and von Lintig, 2015) Correspondingly, Matthew-Wood Syndrome is characterized by visual abnormalities and developmental problems linked to mutations in the human STRA6 gene (Golzio et al., 2007; Pasutto et al., 2007; Isken et al., 2008). The gene discussed is STRA6; the disease is Matthew-Wood syndrome.