Abnormal expression of Lck and NF-κB can be found in autoimmune diseases and malignancies, including rheumatoid arthritis (RA) (Romagnoli et al., 2001; Herrington et al., 2016), systemic lupus erythematosus (SLE) (Matache et al., 2001; Barrera-Vargas et al., 2014), acute T cell lymphocytic leukemia (T-ALL) (Han et al., 2014; Gao et al., 2019), and human chronic lymphocytic leukemia (CLL) (Shinohara et al., 2005; Zanesi et al., 2012). The gene discussed is LCK; the disease is B-cell chronic lymphocytic leukemia.