Tgfβ2−/− mice exhibit multiple axial and appendicular skeletal patterning defects including kyphoscoliosis, fused vertebral column, abnormal curvature of the ribs, fused ribs, bifid ribs, and bifurcation of the sternum in mice (Sanford et al., 1997; Oka et al., 2007). The gene discussed is TGFB2; the disease is Kyphoscoliosis.