The ATTR variants widely exist in patients with familial amyloid polyneuropathy and familial amyloid cardiomyopathy, which can also be detected by Pittsburgh compound B (PIB)- positron emission tomography (PET) in the leptomeningeal vessels of cerebrum, cerebellum, brainstem, and spinal cord of CAA patients (Cavallaro and Klunk, 2016). The gene discussed is TTR; the disease is familial amyloid neuropathy.