Additionally, already approved poly ADP ribose polymerase (PARP) inhibitor, Olaparib, in a TNBC mouse model demonstrated its capacity to induce CD8+ T-cell infiltration via activation of STING (Pantelidou et al., 2019) as well as promote upregulation of PDL1 in several human derived cell lines (Jiao et al., 2017) suggesting that inducing DNA damage may promote a strong anti-tumor immune response through STING activation. This evidence concerns the gene CD274 and neoplasm.