Additionally, it was demonstrated that tumor derived exosomes carry RNA to the type II alveolar cells of the lung stimulating expression of CXCL1, CXCL2, CXCL5 and CXCL12, through engagement with the toll like three receptor (TLR3), which recruit neutrophils (Liu et al., 2016). The gene discussed is CXCL2; the disease is neoplasm.