EGFR and breast cancer: While low oxygen stabilizes HIFs and regulates a hypoxia induced response, receptor tyrosine kinases (RTKs) such as the epidermal growth factor (EGFR) family, which are commonly highly expressed in breast cancers can stabilize HIFs (Lauzier et al., 2007; Lee et al., 2009; Nilsson et al., 2010; Turpin et al., 2016).