HAND2 and cancer: Hsa-miR-16-5p (71, 72), hsa-miR-188-5p (73, 74), lncRNA ADAMTS9-AS1 (75) and LncRNA HAND2-AS1 (76), which are anti-cancer factors, and hsa-miR-192-3p (77), lncRNA MAFG-AS1 (78,79) and lncRNA HAGLR (80), which are pro-cancer factors, are involved in the COAD process by regulating proliferation, apoptosis and EMT phenotype.