In the present study, we identified 77 DE-EMTRGs in the TCGA-cohort, and they were involved in EMT-related terms, including “negative regulation of cell migration” and “leukocyte migration.” Based on 77 DE-EMTRGs, we developed an RS model consisting of 5 prognostic biomarkers (COMP, MYL9, PCOLCE2, SCG2, TIMP1), and demonstrated that the five-EMTRG prognostic signature can be used as an independent prognostic factor for COAD patients with good clinical utility. The gene discussed is PCOLCE2; the disease is colon adenocarcinoma.