Our results demonstrated that DSS colitis upregulated SP, HA, BK, PGI2, and 5-HT expression in the skin and increased TRPV1, TRPA1, and TH in L6 DRG, implying that DSS promoted surface neurogenic inflammation evoked by sympathetic-sensory coupling in skin-DRG. This evidence concerns the gene TRPV1 and colitis.