Nishioka et al. (2019) used transgenic tau mice to observe the diffusion change pattern caused by Aβ injection into LGN, and the change first appeared in the LGN and optic tract, and then in the optic nerve, implying that there is a process of trans-synaptic axonal retrograde lesions in the visual pathway of AD mice. Similarly, Sun et al. (2014) injected Aβ1-42 into the left ventricle of the mouse model, and DTI showed reduced FA and significantly increased RD in the optic nerve and optic tract 2 months later. The gene discussed is MAPT; the disease is Alzheimer disease.