NTRK1 and malignant pleural mesothelioma: Several AD-lifespan-related pathways identified in the present study were also related to cancer, such as positive regulation of cell death, Malignant pleural mesothelioma, Hippo signaling pathway in the downregulated DEGs and apoptotic cell clearance, Signaling by Receptor Tyrosine Kinases in the upregulated DEGs.