HDAC2 and endothelial dysfunction: Some of the associations between genes that changed expression in smokers with inflammation, endothelial dysfunction, and tissue injury can be explained as follows: in Table 2, it is known that an increase in histone deacetylase2 (HDAC2) expression, which is also caused by nicotine, hydroquinone, and benzo(a)pyrene compound, happens in smokers.