In contrast, we observed decreased expressions of several genes related to regulatory T cells (Treg) differentiation and function (IGF2, TGFBR2, TGFBR3), and cancer cell invasiveness (ANGPTL2, IL33, ITGA7, PCSK5, PCSK6, PTPRB, TBX3, TGFBR2, TGFBR3) (Fig. 5D). This evidence concerns the gene TBX3 and cancer.