Unexpectedly, compared to Bhigh/TERTlow HNSCC tumors, we found that the Bhigh/TERThigh profile was significantly associated with increased expression of AICDA (P = 0.010, log2FC = 0.585) and APOBEC3B (P = 0.017, log2FC = 0.476) in HPV-negative HNSCC tumors (Fig. S5B). Here, APOBEC3B is linked to head and neck squamous cell carcinoma.