Fifty percent (50%) of Bhigh/TERThigh patients were HPV-positive vs. ∼20% in the Bhigh/TERTlow group (odds ratio = 4.13; P = 0.002) (Fig. 3B), consistent with the induction of TERT by the E6 protein expressed in HPV + HNSC tumor cells. This evidence concerns the gene TERT and neoplasm.