PCSK5 and cancer: In contrast, we observed decreased expressions of several genes related to regulatory T cells (Treg) differentiation and function (IGF2, TGFBR2, TGFBR3), and cancer cell invasiveness (ANGPTL2, IL33, ITGA7, PCSK5, PCSK6, PTPRB, TBX3, TGFBR2, TGFBR3) (Fig. 5D).