Her serum alpha‐fetoprotein (AFP) and protein induced by vitamin K absence or antagonist‐II (PIVKA‐II) dropped once following the RFA, but they rose again persistently (AFP, 1377.7 ng/mL on April 1, 502.2 ng/mL on April 9, 731.3 ng/mL on May 11, 16962.3 ng/mL on June 22, PIVKA‐II, 45 mAU/mL on April 1, 24 mAU/mL on April 9, 62 mAU/mL on May 11, 282 mAU/mL on June 22 [Figure 1]), and on June 29, 2020, a recurrent tumor with a diameter of about 30 mm was found in S8, accompanied with an occlusive portal vein thrombus in P8 again (Figure 2). This evidence concerns the gene AFP and neoplasm.