Contradictory mechanisms mainly include 1) can be used as fuel mitochondrial respiration in glycolytic tumour cells; 2) promote MMP-2, HIF-1α, VEGF, miR-774/ARHGAP5 axis which promote metastasis, angiogenesis, migration and invasion; 3) immunomodulatory effect on T cells, macrophages, and CTL may lead to tumour immune escape. The gene discussed is VEGFA; the disease is neoplasm.