Shift from CT4 to CT2 possessing significantly higher levels of SLPI, GROa, and MIP3a and significantly lower levels of ICAM-1;Highly diverse microbiota are associated with the enhanced resilience of bacterial vaginosis to standard metronidazole treatment;CD4+ cells from the lamina propria were significantly higher in CT4. The gene discussed is CXCL1; the disease is bacterial vaginosis.