Different members of the Toll like receptors (TLR) family, including TLR1, TLR2, TLR4 and TLR6 have been implicated in mycobacterial infection recognition (Takeuchi and Akira, 2002; D’Avila et al., 2006; Mattos et al., 2011a; Almeida et al., 2014). Here, TLR2 is linked to mycobacterial infectious disease.