APOE and Alzheimer disease: In models including PRS and APOE-ε4 status, a higher global PRS (β = 1.91, t-value = 11.01, p < 0.001) and number of APOE-ε4 alleles (β = 0.94, t-value = 8.60, p < 0.001) were significantly associated with an Alzheimer’s dementia diagnosis.