IFNAR1 and infection: Consistent with these findings, we also observed for IFNAR1-disrupted cells an increase in SARS-CoV-2 RNA associated with both the conditioned media (Fig 3B) and cell monolayer (Fig 3C), as well as an increase in luminescence during infection with a SARS-CoV-2 nanoluciferase reporter virus38 (Fig 3D).