An example of an easy-level difficulty descriptive question was, “What are the first-line treatments for Stage IA mycosis fungoides?” An example of a medium-level difficulty descriptive question was, “Which patients with well-differentiated thyroid cancer should receive postoperative radioactive iodine ablation?” An example of a hard-level difficulty binary question was, “Can we start angiotensin receptor-neprilysin inhibitors immediately after discontinuing an angiotensin-converting enzyme inhibitor?” For additional example questions and answers, see Table 1. This evidence concerns the gene ACE and thyroid cancer.