We note that PPARα/γ agonists or antagonists alone failed to alter basal anxiety levels, while PPARα or PPARγ antagonism only partially reduced Δ9-THC-induced anxiety, suggesting that in addition to PPARα/γ, other receptor (such as CB1 and CB2) mechanisms are also involved in Δ9-THC’s affective effects5. The gene discussed is CNR2; the disease is Anxiety.