The direct and indirect roles of other immunomodulatory interleukins, such as IL-10 (111), and the IL-12 family cytokines (112, 113), the gut microbiome (known to change based on diets and obesity) and adipocyte-derived chemoattractants such as MCP1 (also known to change in obesity (112),) are multifactorial and would benefit from further investigation (114). The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.