Obesity is correlated with an increase in BMAds in mice (13) and humans (126), which are known contributors to systemic adipokines such as leptin (pro-myeloma) (94) and adiponectin (anti-myeloma) (95), however the relationship between MM and BMAds has only begun to be investigated. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.