The univariate logistic regression analysis revealed that age, BMI, diabetic duration, SBP, DBP, TC, TG, apoA, FBG, HbA1c, ALT, AST, AAR, TBIL, serum ALB, WBC, neutrophil and lymphocyte counts, NLR, fibrinogen, serum Cr, eGFR, urinary ACR, ABI, HSL, and prevalence of NAFLD, DN, DR, hypertension, CHD, DFU, PAD were significantly associated with the presence of DPN (P<0.01 or P<0.05).Multivariable logistic regression analysis showed that age, TyG, AAR, serum ALB, and DFU were significantly and independently associated with the presence of DPN (P<0.01 or P<0.05). The gene discussed is ALB; the disease is peripheral arterial disease.