Patients with DPN had significantly older age, longer diabetic duration, higher SBP, FBG, HbA1c, AAR, WBC, neutrophil counts, NLR, fibrinogen, serum Cr, urinary ACR, VPT, prevalence of DN, DR, hypertension, CHD, DFU, PAD, and lower BMI, DBP, TC, TG, apoA, ALT, AST, TBIL, GGT, serum ALB, lymphocyte counts, eGFR, ABI, HSL, and prevalence of NAFLD than those without DPN (P<0.01 or P<0.05). This evidence concerns the gene GPT and Hypertension.