Similar to ginseng Rd, resveratrol, as a SIRT1 agonist, can improve the balance between mitophagy and mitochondrial biogenesis by activating the SIRT1/PGC1a signaling pathway, and significantly reduce age-related cochlear hair cell loss, Spiral ganglion neuron loss, stria vascular atrophy, and hearing threshold changes in C57BL/6 mice (Xiong et al., 2019). Here, SIRT1 is linked to Atrophy.