First, we showed that compared with Kir2.1 (–) mice, Kir2.1 (+) mice spent more time reaching the escape platform during the 5-day training session (Figure 3A) and less time in the target quadrant during probe testing (Figure 3B), indicating learning and memory impairments in Kir2.1 (+) mice, while no obvious difference in swimming speed in MWM and travel distance in the open field was found between Kir2.1 (–) and Kir2.1 (+) mice (Supplementary Figure 1). The gene discussed is KCNJ2; the disease is memory impairment.