However, with the recognition that the breakdown of biochemical homeostasis in people with schizophrenia extends beyond the CNS (Scarr et al., 2015; Lai et al., 2016a) some consideration should be given as to whether CHRM1 / CHRM4-mediated biochemical abnormalities in people with the disorder could extend beyond the CNS. The gene discussed is CHRM1; the disease is schizophrenia.