The high expression of lncRNA ZNFX1 antisense RNA 1 (ZFAS1) in gastric cardia adenocarcinoma (GCA) assists EPAS1 to enhance the epigenetic silencing of HIF-1α and promote the proliferation and metastasis of cancer cells (Zhu et al., 2020). Here, ZFAS1 is linked to gastric cardia adenocarcinoma.