PTEN and gastric cancer: In addition, the study found that in GC cells after radiation exposure, inhibition of the miR-221/222 cluster can upregulate the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in GC cells, activate phosphatidylinositol-3-hydroxykinase (PI3K)/Akt signaling pathway, induce apoptosis, and enhance the radiosensitivity of GC cells (Chun-Zhi et al., 2010).