In another study of folic-acid-induced AKI, Gal3 expression was elevated in injured tubules after folic acid administration, and Gal3 inhibition reduced proinflammatory cytokines, renal fibrosis, and apoptosis at 2 weeks post-injury (Kolatsi-Joannou et al., 2011). Here, LGALS3 is linked to acute kidney injury.