In contrast, a study by Volarevic et al. (2019) reported that cisplatin-induced apoptosis was exacerbated in Gal3 knockout mice and WT mice that received a Gal3 inhibitor, while recombinant Gal3 blunted apoptosis in Gal3 deficient mice with cisplatin-induced AKI. This evidence concerns the gene LGALS3 and acute kidney injury.