LGALS3 and hypertensive nephropathy: Frenay et al. (2015) also demonstrated that inhibition of Gal3 attenuated hypertensive nephropathy in rats, as evident by improved kidney function, reduced proteinuria, and decreased structural kidney damage (Frenay et al., 2015). In another murine hypertension model, Gal3 inhibition was observed to attenuate renal inflammation and fibrosis in experimental hyperaldosteronism, independent of blood pressure (Martinez-Martinez et al., 2015).