Similarly, in a rat IRI AKI model utilizing unilateral renal pedicle clamping, inhibition of Gal3 by modified citrus pectin (MCP) significantly attenuated the rise in creatinine and blood urea nitrogen (BUN), as well as the degree of tubular injury compared to controls (Sun et al., 2021a). The gene discussed is LGALS3; the disease is acute kidney injury.