In general, different stimulus induce muscle atrophy via different mechanisms and denervated muscle atrophy is involved in increased protein degradation, increased oxidative stress, activated autophagy, mitochondrial dysfunction, lasting inflammation and fibrosis (Rebolledo et al., 2019), which complement the function of the OPG/RANKL/RANK axis in muscles from a different perspective by modeling denervation-induced muscle atrophy. This evidence concerns the gene TNFRSF11A and Atrophy.