NLRP3 and major depressive disorder: It has also been reported the Nod-like receptor pyrin containing three inflammasome (NLRP3), which is one of the key components involved in activating inflammatory cytokines, is increased in the peripheral blood mononuclear cells of patients suffering from MDD, while its level is decreased by the tricyclic antidepressant amitriptyline (Alcocer-Gomez et al., 2014).