One study reported that exogenous BMP-7 significantly decreases plaque formation following the induction of atherosclerosis by inhibiting M1 macrophage differentiation and promoting M2 polarization, whereas macrophage depletion abolishes this beneficial effect in Apoe−/− mice (Singla et al., 2016; Shoulders et al., 2019). This evidence concerns the gene BMP7 and atherosclerosis.