Interestingly, however, deletion of Dlg1 in microglia inhibits microglial activation and ameliorates depression-like behavior in both the LPS- and CRS-induced models of depression, prompting us to hypothesize that Dlg1 deletion protects the animal from depression more than by targeting NF-κB signaling but restores microglia to homeostasis from a state of stress-induced dysregulation. This evidence concerns the gene DLG1 and major depressive disorder.