Importantly, TSP1 upregulation was also seen in both murine models of DKD and human type 1 and 2 diabetic kidneys (Yevdokimova et al., 2001; Wahab et al., 2005; Hohenstein et al., 2008; Lu et al., 2011; Murphy-Ullrich, 2019). The gene discussed is THBS1; the disease is diabetic kidney disease.