To date, approximately 4000 clinical trials focusing on programmed cell death protein-1/programmed cell death protein ligand-1 (PD-1/PD-L1) inhibitors have been carried out in at least 20 types of cancer, including both solid and hematological tumors; the total number of subjects worldwide is more than 20,000 (Chen et al., 2020). The gene discussed is CD274; the disease is cancer.